Secondary Infections and Mortality in COVID-19

Zhou et al. reported in the Lancet that in 50% of fatal cases a secondary infection which occurred at of median of 17 days. Moreover, 100% of fatal developed sepsis/viremia at a median of 10 days.

Raises the possibility of a strong compensatory anti-inflammatory response/immunoparalysis effect compounded with lymphopenia. Timing of corticosteroids and immunomodulatory therapies are a point of concern.

Curious what type of secondary infections you are seeing (if any) in your ICU?

Lippi and Plebani recommended serial procalcitonin measurement in hospitalized patients with COVID-19, as they found a nearly 5-fold higher risk of severe SARS-CoV-2 infection with an elevated PCT. (https://www.sciencedirect.com/science/article/pii/S0009898120301066?via%3Dihub)

I’m recently retired RN. Forgive me if this has been answered. With hospitals currently incubators of MRSA and C. Diff, why isn’t the COVID patient begun on anti-biotics along with all of the other meds utilized? As I understand it, this virus interacts with bacterium to finish off the immune system.

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